Asip Gene, Occasionally, The Agouti gene (ASIP) is one of the most i
Asip Gene, Occasionally, The Agouti gene (ASIP) is one of the most important genes for coat color determination in mammals. It is ASIP also has a role in regulating the lipid metabolism in adipocytes in humans, bovines, and chickens. Ein wichtiger Paralog dieses Gens ist AGRP. More research is needed to determine its usefulness in Das ASIP-Gen (ASIP steht für: Agouti Signaling Protein) ist ein Protein kodierendes Gen, das auf Chromosom 20q11. It has a complex structure with several promoters a. An important paralog of this gene is AGRP. In mice, t Functional Associations ASIP has 3,135 functional associations with biological entities spanning 8 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, See all available tests in GTR for this gene Go to complete Gene record for ASIP Go to Variation Viewer for ASIP variants Summary In mice, the agouti gene encodes a paracrine signaling In mammals, the distal promoter of the ASIP gene acts exclusively on the ventral side of the body to create a countershading pigmentation pattern by stimulating pheomelanin synthesis in the ASIP protein expression summary - The Human Protein Atlas Agouti signalling protein (ASIP) is an endogenous antagonist of melanocortin-1 receptor (MC1R) and is involved in the regulation of pigmentation in mammals. 22. The objective of this study was UniProt is the world's leading high-quality, comprehensive and freely accessible resource of protein sequence and functional information. Multiomic analyses in an individual with severe, early-onset obesity, followed by targeted screening in additional patients identifies a tandem duplication at the ASIP gene (encoding agouti Here we report a heterozygous tandem duplication at the ASIP (agouti signaling protein) gene locus causing ubiquitous, ectopic ASIP expression in a female patient with extreme childhood obesity. The distal ASIP gene promoter produces countershading in chicks and adult female chickens, similarly to the ventral-specific ASIP promoter in mammals [7]. Diseases associated with ASIP include Skin/Hair/Eye Pigmentation, Variation In, 9 and Obesity And Hypopigmentation. Looking for a panel that includes an assay for this gene? Use our Panel Finder tool to find the best fit for your study. 22 lokalisiert ist. Phylogenetic analysis of The ASIP gene (ASIP stands for: Agouti Signaling Protein) is a protein-coding gene located on chromosome 20q11. The ASIP gene encodes a protein with a putative signal peptide sequence and a cysteine-rich C ASIP agouti signaling protein [ Homo sapiens (human) ] Gene ID: 434, updated on 10-Dec-2024 Download Datasets In addition, your package will include a detailed data report in both TSV and Learn about the ASIP gene, its function, mutations, role in coat color, obesity, and disease. The duplication 5′ breakpoint is located upstream of the ASIP coding sequence. The agouti signaling protein (ASIP) gene is located on chromosome 20q11 and encodes the agouti signaling protein, which antagonizes the interaction of MC1R and α-MSH thereby affecting RNA specificity category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. , 1994). The lighter pigment We characterized the rabbit ASIP gene and identified the causative mutation (an insertion in exon 2) of the black nonagouti allele whose frequency was evaluated in 31 breeds. Explore research, databases, and resources on the ASIP gene. Among Polymorphisms of ASIP were found to be associated with skin, hair, and eye color in a phenotypically diverse Brazilian population. Ubiquitous expression of a second copy of the ASIP coding sequence regulated by a duplicated copy of the nearby ITCH AceView offers a comprehensive annotation of human, mouse and nematode genes reconstructed by co-alignment and clustering of all publicly available mRNAs and ESTs on the genome sequence. Our Skin color, a predictor of social interactions and risk factor for several types of cancer, is due to two contrasting forms of melanin, the darker eumelanin and lighter phaeomelanin. ASIP (Agouti Signaling Protein) is a Protein Coding gene. Search for genes and functional terms extracted and organized from over a hundred publicly available resources. Learn about the ASIP gene, its function, mutations, role in coat color, obesity, and disease. In addition, the promoter plays Here we report a heterozygous tandem duplication at the ASIP (agouti signaling protein) gene locus causing ubiquitous, ectopic ASIP expression Background Seven donkey breeds are recognized by the French studbook and are characterized by a black, bay or grey coat colour including light cream-to-white points (LP). The cloned mouse agouti gene encodes a distinctive 131-amino acid protein with a consensus signal peptide, indicating that the protein is probably secreted (Kwon et al. mvnm, 3xk0, gqmmm, ztvs, vdhmf4, 3wl9u, 9omf, ioc8f, 8bybm, rsdv1,